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Genome-wide identification of enhancers in skeletal muscle

ABSTRACT: In an effort to identify the compendium of regulatory elements that govern myogenic differentiation, we generated chromatin state maps based on the recruitment of factors (p300 and PolII) and histone modifications (H3K4me1, H3K27ac) that typify enhancers in myoblasts and myotubes. We found a remarkable concordance between the location of these newly defined, active enhancers and MyoD1 binding events. In addition, we found a striking association between the position of enhancers and RNA polymerase II recruitment, which resulted in the expression of previously disclosed non-coding RNAs, as well as potentially new transcripts identified ab initio, throughout the enhancer region.

ORGANISM(S): Mus musculus

PROVIDER: GSE37525 | GEO | 2012/12/15

SECONDARY ACCESSION(S): PRJNA161011

REPOSITORIES: GEO

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Genome-wide identification of enhancers in skeletal muscle

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