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Genome-wide analysis of E157D PPARγ transcriptional activity in NIH-3T3 fibroblasts

ABSTRACT: The E157D PPARγ mutation presents as an atypical case of familial partial lipodystrophy and diabetes in a human cohort and has a novel molecular mechanism. The mutation is located in the DNA-binding domain, has no dominant negative activity but disrupts transcription activation after the protein has bound the DNA. The mutation causes a transcriptional activation defect on many PPARγ target genes, while some genes are induced normally. A small number of non-PPARγ target genes are induced by the E157D mutant, possibly leading to the atypical features in this cohort.

ORGANISM(S): Mus musculus

PROVIDER: GSE37990 | GEO | 2012/05/16

SECONDARY ACCESSION(S): PRJNA167030

REPOSITORIES: GEO

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