Expression analysis of control and low protein fed mouse offspring subsequently treated with multiple low doses of STZ

ABSTRACT: Low protein (LP) during gestation leads to low birth weight and poor fetal growth, with altered islet development and glucose intolerance in adulthood. Additionally, LP offspring fail to regenerate their β-cells following depletion with streptozotocin (STZ), in contrast to control-fed offspring that are capable of β-cell regeneration. Our objective was to identify genes and signalling pathways that may be critically altered in LP offspring rendering them susceptible to develop long term glucose intolerance and decreased β-cell plasticity.

ORGANISM(S): Mus musculus

PROVIDER: GSE38215 | GEO | 2013/06/01

SECONDARY ACCESSION(S): PRJNA167451

REPOSITORIES: GEO