Transcriptomics

Dataset Information

0

Expression analysis of the glucose deprivation-induced human tumor cell responses


ABSTRACT: The tumor microenvironment is characterized by low glucose and hypoxia. It is well known that changes in the tumor microenvironment, such as hypoxia and low glucose, can increase the production of VEGF. Although the role of hypoxia in the regulation of VEGF production is well understood, the mechanism linking glucose deprivation (GD) to tumor growth and angiogenesis is unclear. Here, GD (a physiological stimulus) was used to treat human tumor cells. The transcriptional reprogramming of tumor cells by GD was measured with microarray technology to provide a comprehensive analysis of the gene expression profile underlying the GD treatment. Our study suggested that GD initiates an angiogenic switch by increasing the expression of proangiogenic mediators (VEGF, FGF2, IL6, etc.) and decreasing the expression of angiogenesis inhibitors (THBS1, CXCL14 and CXCL10). The markers of Unfolded Protein Response (UPR) (Grp78/Bip, CHOP, ATF4, etc.) were significantly increased. The above results suggest GD may regulate angiogenesis through activation of the UPR.

ORGANISM(S): Homo sapiens

PROVIDER: GSE38583 | GEO | 2012/10/25

SECONDARY ACCESSION(S): PRJNA168162

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-10-25 | E-GEOD-38583 | biostudies-arrayexpress
2011-05-13 | E-GEOD-21979 | biostudies-arrayexpress
2016-01-15 | E-GEOD-70208 | biostudies-arrayexpress
2012-10-11 | E-GEOD-32911 | biostudies-arrayexpress
2011-05-13 | GSE21979 | GEO
2016-01-15 | GSE70208 | GEO
2012-10-11 | GSE32911 | GEO
2013-10-30 | E-GEOD-51775 | biostudies-arrayexpress
2013-10-30 | E-GEOD-51802 | biostudies-arrayexpress
2022-07-05 | GSE179509 | GEO