Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules
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ABSTRACT: To increase our understanding of the mechanisms that underlie neuroprotection following glutamate receptor-induced excitotoxicity, we treated primary CD-1 mouse cortical neurons with NMDA in the presence of absence of neuroprotective compounds. The results indicate a convergence at the level of whole genome expression, despite the divergent chemistries and purported mechanisms of action. While more arrays were performed than published, only the extreme arrays were used in subsequent analyses.
ORGANISM(S): Mus musculus
PROVIDER: GSE38701 | GEO | 2015/01/01
SECONDARY ACCESSION(S): PRJNA168448
REPOSITORIES: GEO
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