Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparative trascriptomic analysis between early-blastocyst and Hatched blastocyst

ABSTRACT: Comparative trascriptomic analysis between porcine early-blastocyst and Hatched blastocyst collected around day 5-6

ORGANISM(S): Sus scrofa

PROVIDER: GSE38882 | GEO | 2015/06/21

SECONDARY ACCESSION(S): PRJNA169136

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Comparative trascriptomic analysis between early-blastocyst and Hatched blastocyst

Project description:Comparative trascriptomic analysis between porcine early-blastocyst and Hatched blastocyst collected around day 5-6 direct comparison with dye-swap; two different arrays with 6 Samples each

2015-06-21 | E-GEOD-38882 | biostudies-arrayexpress

Sus scrofa

Project description:Comparative trascriptomic analysis between early-blastocyst and Hatched blastocyst

| PRJNA169136 | ENA

Transcriptome dynamics in early in vivo developing and in vitro produced porcine embryos

Project description:Background: The transcriptional changes around the time of embryonic genome activation in pre-implantation embryos indicate that this process is highly dynamic. In vitro produced porcine blastocysts are known to be less competent than in vivo developed blastocysts. To understand the conditions that compromise developmental competence of in vitro embryos, it is crucial to evaluate the transcriptional profile of porcine embryos during pre-implantation stages. In this study, we investigated the transcriptome dynamics in in vivo developed and in vitro produced 4-cell embryos, morulae and hatched blastocysts. Results: In vivo developed and in vitro produced embryos displayed largely similar transcriptome profiles during development. Enriched canonical pathways from the 4-cell to the morula transition that were shared between in vivo developed and in vitro produced embryos included oxidative phosphorylation and EIF2 signaling. The shared canonical pathways from the morula to the hatched blastocyst transition were 14-3-3-mediated signaling, xenobiotic metabolism general signaling pathway, and NRF2-mediated oxidative stress response. The in vivo developed and in vitro produced hatched blastocysts were compared to identify molecular signaling pathways indicative of lower developmental competence of in vitro produced hatched blastocysts. A higher metabolic rate and expression of the arginine transporter SLC7A1 were found in in vitro produced hatched blastocysts. Conclusions: Our findings suggest that embryos with compromised developmental potential are arrested at an early stage of development, while embryos developing to the hatched blastocyst stage display largely similar transcriptome profiles, irrespective of the embryo source. The hatched blastocysts derived from the in vitro fertilization-pipeline showed an enrichment in molecular signaling pathways associated with lower developmental competence, compared to the in vivo developed embryos.

2021-01-30 | GSE155043 | GEO

Day5-6 porcine blastocyst gene expression profile

Project description:Day5-6 porcine blastocyst gene expression profiling dye-swaped loop design with 3 biological replicates of Day5-6 blastocyst

2015-06-22 | E-GEOD-38923 | biostudies-arrayexpress

Day5-6 porcine blastocyst gene expression profile

Project description:Day5-6 porcine blastocyst gene expression profiling

2015-06-22 | GSE38923 | GEO

Pig Synthetic Blastocyst-like Structures from Embryonic Stem Cells

Project description:We developed an efficient method to generate porcine blastocyst-like structures (termed blastoids) from ESCs.

2024-06-30 | GSE242553 | GEO

mTOR activity paces human blastocyst stage developmental progression (data set 2)

Project description:Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the growth-regulating mTOR signaling pathway1. It is unknown whether this ability is conserved in mammals in general and in humans in particular. Here we show that decreasing the activity of the mTOR signaling pathway induces human pluripotent stem cells (hPSCs) and blastoids to enter a dormant state with limited proliferation, developmental progression, and capacity to attach to endometrial cells. These in vitro assays show that, similar to other species, the ability to enter dormancy is active in human cells around the blastocyst stage and is reversible at both functional and molecular levels. The pacing of human blastocyst development has potential implications for reproductive therapies.

2024-09-26 | PXD036258 | Pride

mTOR activity paces human blastocyst stage developmental progression (data set 1)

2024-08-06 | PXD029513 | Pride

Macrophages from newly hatched chicks [set2]

Project description:To identify markers associated with inherent cellular sex-identity, we analysed macrophages from newly-hatched chicks. We found that male and female macrophages respond differently to stimulation by bacterial lipopolysaccharide and that female macrophages constitutively express higher levels of interferon target genes than male macrophages.

2014-07-31 | GSE59920 | GEO

Transcriptomic analysis of porcine blastocyst form cumulus oocyte complexes matured in coculture with porcine luteal cells

Project description:The transcriptome pattern in blastocyst that developed from cumulus oocyte complexes matured in coculture with porcine luteal cells was investigated.

2020-10-13 | GSE154587 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data