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MicroRNA profiling and clinical outcomes in human osteosarcoma (biopsies)

ABSTRACT: Osteosarcoma is a malignancy with variable outcomes that are not tightly aligned with chemotherapy response. Previous work has suggested a possible role for microRNAs (miRNAs) in determining the susceptibility of osteosarcomas to treatment but formal miRNA-based outcome models have not been reported. Formalin-fixed, paraffin-embedded (FFPE) specimens may be a unique approach for such studies in a rare malignancy. We used supervised principal components analysis and logistic regression to study survival and chemoresponse endpoints, and miRNA activity and gene set analysis algorithms to study miRNA regulatory networks using mRNA data. Our study also creates a paradigm for FFPE-based miRNA clinical biomarker research in rare tumors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE39040 | GEO | 2013/01/22

SECONDARY ACCESSION(S): PRJNA169666

REPOSITORIES: GEO

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