A new structural paradigm in copper resistance in a human pathogen
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ABSTRACT: Copper is essential for both innate and adaptive immune function and copper resistance has emerged as an important determinant of virulence of microbial pathogens. In the human pathogen Streptococcus pneumoniae (Spn), cytoplasmic copper resistance is mediated by an operon encoding the copper-responsive repressor CopY, CupA, of unknown function, and CopA, a copper effluxing P1B-type ATPase. We show that CupA is a novel cell membrane-anchored Cu(I) chaperone for CopA, and that a Cu(I)-binding competent, membrane-localized CupA, like CopA, is obligatory for copper resistance.
ORGANISM(S): Streptococcus pneumoniae
PROVIDER: GSE39176 | GEO | 2013/05/24
SECONDARY ACCESSION(S): PRJNA170764
REPOSITORIES: GEO
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