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Ogt chromatin recruitment is mediated by TET proteins in mouse ES cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE39323 | GEO | 2013/01/06

SECONDARY ACCESSION(S): PRJNA170601

REPOSITORIES: GEO

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Ogt chromatin recruitment is mediated by TET proteins in mouse ES cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-01-06 | E-GEOD-39323 | biostudies-arrayexpress

Ogt chromatin recruitment is mediated by TET proteins in mouse ES cells [ChIP-Seq]

Project description:These data include the genome wide location analysis of Ogt by ChIP of Ogt in mouse ES cells. Precipitation of formaldehyde cross-linked chromatin prepared from mouse ES cell using specific antibody against OGT and IgG as control.

2013-01-06 | E-GEOD-39154 | biostudies-arrayexpress

Ogt chromatin recruitment is mediated by TET proteins in mouse ES cells [expression array]

Project description:O-linked N-acetylglucosamine (O-GlcNAc ) transferase (OGT) activity is essential for embryonic stem (ES) cell viability and mouse development. OGT is present in both cytoplasm and nucleus of different cell types and mediates serine or threonine glycosylation. The Ogt gene locus resides on the X-chromosome and its activity is required for the viability of male ES cells. Using Ogt conditional knock out (KO) ES cells it was shown the failure of establishing stable KO ES clones further suggesting that Ogt activity is required for ES cell self-renewal and pluripotency. For understanding these changes, we performed global gene expression upon silencing of Ogt mediated by esiRNA in mouse Embryonic Stem Cells. Total RNA was extracted from E14 ES cells (derived from Ola129 mice) transiently transfected with Ogt specific and control esiRNA oligos 48 hrs. post-transfection.

2013-01-06 | E-GEOD-39321 | biostudies-arrayexpress

Ogt chromatin recruitment is mediated by TET proteins in mouse ES cells [expression array]

2013-01-06 | GSE39321 | GEO

Ogt chromatin recruitment is mediated by TET proteins in mouse ES cells [ChIP-Seq]

Project description:These data include the genome wide location analysis of Ogt by ChIP of Ogt in mouse ES cells.

2013-01-06 | GSE39154 | GEO