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Differential methylation in discrete developmental stages of the parasitic nematode Trichinella spiralis

ABSTRACT: We present the first study to confirm the existence of DNA methylation in the parasitic nematode Trichinella spiralis, and we characterize the methylomes of the three life-cycle stages of this food-borne infectious human pathogen. We observe a drastic increase in DNA methylation during the transition from the new born to mature stage, and we further identify parasitism-related genes that show changes in DNA methylation status between life cycle stages. We also evaluated differential gene expression among the three life stages using Illumina HiSeq 2000 RNA-seq technology.

ORGANISM(S): Trichinella spiralis

PROVIDER: GSE39328 | GEO | 2012/09/28

SECONDARY ACCESSION(S): PRJNA170655

REPOSITORIES: GEO

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Differential methylation in discrete developmental stages of the parasitic nematode Trichinella spiralis

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