Feed-forward Inhibition of Androgen Receptor Activity by Glucocorticoid Action in Human Adipocytes
Ontology highlight
ABSTRACT: We compared transcriptomes of terminally differentiated mouse 3T3-L1 adipocytes [Series GSE14004] and human adipocytes to identify cell-specific differences. Gene expression and high content analysis (HCA) data identified the androgen receptor (AR) as both expressed and functional, exclusively during early human adipocyte differentiation. We used HCA to determine mechanisms of AR regulation and activity in human adipocytes. We found that AR is regulated in a feed-forward fashion by glucocorticoids.
ORGANISM(S): Homo sapiens
PROVIDER: GSE39342 | GEO | 2012/07/13
SECONDARY ACCESSION(S): PRJNA170682
REPOSITORIES: GEO
ACCESS DATA