Aging time course
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ABSTRACT: Transcriptional Profile of Aging in C. elegans Whole-genome analysis of gene expression during chronological aging of the worm provides a rich database of age-specific changes in gene expression and represents one way to distinguish among these models. Using a rigorous statistical model with multiple replicates, we find that a relatively small number of genes (only 164) show statistically significant changes in transcript levels as aging occurs (<1% of the genome). Expression of heat shock proteins decreases, while expression of certain transposases increases in older worms, and these findings are consistent with a higher mortality risk due to a failure in homeostenosis and destabilization of the genome in older animals. Finally, a specific subset of genes is coordinately altered both during chronological aging and in the transition from the reproductive form to the dauer, demonstrating a mechanistic overlap in aging between these two processes. Groups of assays that are related as part of a time series. Age: Age of organism Keywords: time_series_design
ORGANISM(S): Caenorhabditis elegans
PROVIDER: GSE4005 | GEO | 2006/01/11
SECONDARY ACCESSION(S): PRJNA95223
REPOSITORIES: GEO
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