Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis.
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ABSTRACT: Expression data from Total RNA extracted from murine spleen, liver, lungs, kidneys and hearts. Sepsis was induced in C57Bl/6J mice by cecal ligation and puncture (CLP), followed 6 hours later by an intravenous injection of Mesenchymal Stem Cell (MSC) or saline. Twenty-eight hours after CLP, plasma, bronchoalveolar lavage (BAL) fluid and tissues were collected for analyses. Total RNA was extracted using Trizol (as per manufactures' instruction) followed by clean-up procedure using Qiagen RNA easy Prep (as per manufactures instructions) In the following study we hypothesized that mesenchymal stem cells (MSCs), which have documented immunomodulatory properties, would reduce sepsis-associated inflammation and organ injury in a clinically relevant model of sepsis.
ORGANISM(S): Mus musculus
PROVIDER: GSE40180 | GEO | 2012/12/31
SECONDARY ACCESSION(S): PRJNA173022
REPOSITORIES: GEO
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