Transcriptomics

Dataset Information

0

Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.


ABSTRACT: Multiple FTD patient-specific iPSC lines were generated for the first time, Human neurons of progranulin haploinsufficiency have been established. PGRN S116X neurons are more sensitive to kinase inhibitors-induced cell stress, which can be rescued by ectopic progranulin expression, revealing progranulin-dependent cellular defects in FTD. Microarray analysis reveals that the serine/threonine kinase S6K2 (RPS6KB2) and other genes involved in MAPK signaling are dysregulated specifically in neurons with progranulin deficiency.

ORGANISM(S): Homo sapiens

PROVIDER: GSE40378 | GEO | 2012/10/25

SECONDARY ACCESSION(S): PRJNA173801

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-10-25 | E-GEOD-40378 | biostudies-arrayexpress
2014-11-12 | GSE60902 | GEO
2022-09-18 | PXD035889 | Pride
| S-EPMC3532907 | biostudies-literature
2022-06-03 | GSE163122 | GEO
2024-04-15 | GSE230447 | GEO
2024-04-15 | GSE230519 | GEO
2024-04-15 | GSE230450 | GEO
2010-11-10 | E-GEOD-19211 | biostudies-arrayexpress
2022-08-01 | GSE188498 | GEO