Molecular alterations in prostate carcinomas that associate with in vivo exposure to chemotherapy
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ABSTRACT: Patients with high-risk localized prostate cancer (tumor-node-metastasis ≥ T2b or prostate-specific antigen ≥ 15 ng/mL or Gleason glade ≥ 4+3) were enrolled into a phase II clinical trial of neoadjuvant chemotherapy with docetaxel and mitoxantrone followed by prostatectomy. Pretreatment prostate tissue was acquired by needle biopsy and posttreatment tissue was acquired by prostatectomy. Prostate epithelium was captured by microdissection, and transcript levels were quantitated by cDNA microarray hybridization.
ORGANISM(S): Homo sapiens
PROVIDER: GSE40434 | GEO | 2012/08/29
SECONDARY ACCESSION(S): PRJNA174035
REPOSITORIES: GEO
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