Genomics

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Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin [MNase-Seq]


ABSTRACT: We report that the Schizosaccharomyces pombe CHD remodeler, Hrp3, is a global regulator that drives higher-order chromatin structure and genomic stability. The loss of Hrp3 resulted in nucleosome perturbation across the chromosome, and the production of antisense transcripts in the hrp3∆ cells emphasized the importance of nucleosome architecture for proper transcription

ORGANISM(S): Schizosaccharomyces pombe

PROVIDER: GSE40451 | GEO | 2012/10/02

SECONDARY ACCESSION(S): PRJNA174085

REPOSITORIES: GEO

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