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Expression data of inducible stable cell lines overexpressing Ero1alpha WT and Ero1alpha C104A/C131A

ABSTRACT: The overall cellular response to oxidative stress generated by Ero1α in the lumen of the mammalian endoplasmic reticulum (ER) is poorly characterized. Here, we investigate the effects of overexpressing a hyperactive mutant (C104A/C131A) of Ero1α. Using microarray analysis, we demonstrate that the cell reacts to the oxidative challenge caused by Ero1α hyperactivity by turning on the unfolded protein response. Our findings suggest that the hyperoxidation generated by Ero1α-C104A/C131A is addressed in the ER lumen and is unlikely to exert oxidative injury throughout the cell.

ORGANISM(S): Homo sapiens

PROVIDER: GSE40601 | GEO | 2012/09/07

SECONDARY ACCESSION(S): PRJNA174364

REPOSITORIES: GEO

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Expression data of inducible stable cell lines overexpressing Ero1alpha WT and Ero1alpha C104A/C131A

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