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Expression data from vehicle or PD-0332991 treated human T-ALL lines

ABSTRACT: Cyclin D3 is critical hematopoiesis and loss of cyclin D3 leads to resistance to transformation of bone marrow progenitors by Notch1-IC. We used a small molecule targeting cyclin D3:CDK4/6 activity to study whether its inhibition is an effective therapeutic strategy. We analyzed T-ALL lines in vitro with PD-0332991 or vehicle control to determine genes affected by the drug.

ORGANISM(S): Homo sapiens

PROVIDER: GSE40635 | GEO | 2012/12/13

SECONDARY ACCESSION(S): PRJNA174438

REPOSITORIES: GEO

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Expression data from vehicle or PD-0332991 treated human T-ALL lines

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