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Gata2 is a master regulator of endometrial function and progesterone signaling

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE40661 | GEO | 2014/01/01

SECONDARY ACCESSION(S): PRJNA174521

REPOSITORIES: GEO

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Gata2 is a master regulator of endometrial function and progesterone signaling

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-01-01 | E-GEOD-40661 | biostudies-arrayexpress

Gata2 is a master regulator of endometrial function and progesterone signaling [Affymetrix]

Project description:The role of Gata2 in regulating uterine function including fertility, implantation, decidualization and P4 signaling in the mouse was investigated by the conditional ablation of Gata2 in the uterus using the (PR-cre) mouse and ChIP-seq for in vivo GATA2 binding sites in the murine uterus upon acute P4 administration. Gata2 gene ablation was confirmed by real-time PCR analysis in the PR-cre; Gata2fl/fl (termed Gata2d/d) uterus. While littermate controls are fertile, Gata2d/d females are completely infertile. Analysis of the infertility indicates that implantation does not occur, and the uterine stroma is incapable of undergoing the decidual reaction to support further embryonic development. Measure of P4 target genes including PR itself indicate a block in P4 target gene induction and that Gata2 regulates PR expression directly. Microarray analysis demonstrates that ablation of Gata2 leads to specific gene changes, including disruption of the Wnt signaling pathway, Progesterone receptor (PR) signaling, and Ihh signaling pathway. In addition we identified 46,183 GATA2 binding sites in P4 treatment conditions with 7,954 binding sites overlapping that of the PR.Taken together, these data demonstrate that Gata2 is a critical regulator of gene expression and function in the murine uterus.

2014-01-01 | E-GEOD-40660 | biostudies-arrayexpress

Gata2 is a master regulator of endometrial function and progesterone signaling [ChIP-Seq]

2014-01-01 | E-GEOD-40659 | biostudies-arrayexpress

Gata2 is a master regulator of endometrial function and progesterone signaling [Affymetrix]

2014-01-01 | GSE40660 | GEO

Gata2 is a master regulator of endometrial function and progesterone signaling [ChIP-Seq]

2014-01-01 | GSE40659 | GEO

Gata2 is a master regulator of endometrial function and progesterone signaling

Project description:Gata2 is a master regulator of endometrial function and progesterone signaling

| PRJNA174521 | ENA

GATA2 and progesterone receptor interaction in endometrial stromal cells undergoing decidualization

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-02-22 | GSE145674 | GEO

A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function.

Project description:Altered progesterone responsiveness leads to female infertility and cancer, but underlying mechanisms remain unclear. Mice with uterine-specific ablation of GATA binding protein 2 (Gata2) are infertile, showing failures in embryo implantation, endometrial decidualization, and uninhibited estrogen signaling. Gata2 deficiency results in reduced progesterone receptor (PGR) expression and attenuated progesterone signaling, as evidenced by genome-wide expression profiling and chromatin immunoprecipitation. GATA2 not only occupies at and promotes expression of the Pgr gene but also regulates downstream progesterone responsive genes in conjunction with the PGR. Additionally, Gata2 knockout uteri exhibit abnormal luminal epithelia with ectopic TRP63 expressing squamous cells and a cancer-related molecular profile in a progesterone-independent manner. Lastly, we found a conserved GATA2-PGR regulatory network in both human and mice based on gene signature and path analyses using gene expression profiles of human endometrial tissues. In conclusion, uterine Gata2 regulates a key regulatory network of gene expression for progesterone signaling at the early pregnancy stage.

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A Gata2 dependent transcription network regulates progesterone signaling and endometrial function

Project description:Gata2 dependent genes in mouse uteri were identified by the conditional ablation of Gata2 using the (PR-cre) mouse upon acute progesterone administration.

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Pruning of the adipocyte cistrome by hematopoietic master regulator PU.1

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-06-27 | E-GEOD-48345 | biostudies-arrayexpress