Transcriptomics

Dataset Information

0

Transcriptional response of Escherichia coli O157:H7 to cinnamaldehyde


ABSTRACT: Cinnamaldehyde is a natural antimicrobial and has been found to be effective against many foodborne pathogens including Escherichia coli O157:H7. Although its antimicrobial effects have been well investigated, limited information is available on its effects at the molecular level. Sublethal treatment at 200 mg/l cinnamaldehyde inhibited growth of E. coli O157:H7 at 37oC and for ≤ 2 h caused cell elongation, but from 2 to 4 h growth resumed and cells reverted to normal length. To understand this transient behaviour, genome-wide transcriptional analysis of E. coli O157:H7 was performed at 2 and 4 h exposure to cinnamaldehyde. Drastically different gene expression profiles were obtained at 2 and 4 h. At 2 h exposure, cinnamaldehyde induced overexpression of many oxidative stress-related genes, reduced DNA replication, and synthesis of protein, O-antigen and fimbriae. At 4 h, many cinnamaldehyde-induced repressive effects on E. coli O157:H7 gene expressions were reversed and oxidatve stress genes were nolonger differentially expressed.

ORGANISM(S): Escherichia coli Escherichia coli O157:H7

PROVIDER: GSE40693 | GEO | 2012/09/08

SECONDARY ACCESSION(S): PRJNA174627

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-09-08 | E-GEOD-40693 | biostudies-arrayexpress
2012-07-05 | GSE30424 | GEO
2009-10-05 | GSE17519 | GEO
2011-11-22 | GSE28144 | GEO
2019-05-02 | GSE125633 | GEO
2015-07-29 | E-GEOD-49367 | biostudies-arrayexpress
2008-10-11 | GSE13132 | GEO
2023-03-10 | GSE226409 | GEO
2017-07-24 | GSE15265 | GEO
2017-07-24 | GSE15261 | GEO