Transcriptomics

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Th2 cytokine IL-4 is critical in initiating pulmonary vascular inflammation under hypoxic conditions and induces pulmonary vascular endothelial cell activation.


ABSTRACT: IL-4-mediated pro-inflammatory vascular responses have been implicated in the pathogenesis of chronic cardiopulmonary diseases. Our results show that hypoxia-induced collagen synthesis and early recruitment of inflammatory cells are significantly less in the lungs of IL-4 knockout (KO) mice than in those of wild-type mice. In addition, we found that IL-4 significantly increased pro-inflammatory genes in primary pulmonary microvascular endothelial cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE40999 | GEO | 2013/09/19

SECONDARY ACCESSION(S): PRJNA175515

REPOSITORIES: GEO

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