Transcriptomics

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Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Cell Composition


ABSTRACT: By applying RNA-ISH and RNAseq to circulating tumor cells (CTCs), the study provides definitive evidence of epithelial to mesenchymal transition (EMT) across all histological types of breast cancer, identifying mediators such as FOXC1 and TGF-β signaling, and demonstrating dynamic treatment-associated changes in EMT within clusters of CTCs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE41245 | GEO | 2013/02/01

SECONDARY ACCESSION(S): PRJNA176307

REPOSITORIES: GEO

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