Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Cell Composition
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ABSTRACT: By applying RNA-ISH and RNAseq to circulating tumor cells (CTCs), the study provides definitive evidence of epithelial to mesenchymal transition (EMT) across all histological types of breast cancer, identifying mediators such as FOXC1 and TGF-β signaling, and demonstrating dynamic treatment-associated changes in EMT within clusters of CTCs.
ORGANISM(S): Homo sapiens
PROVIDER: GSE41245 | GEO | 2013/02/01
SECONDARY ACCESSION(S): PRJNA176307
REPOSITORIES: GEO
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