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The evolutionary landscape of alternative splicing in vertebrate species

ABSTRACT: How species with similar repertoires of protein coding genes differ so dramatically at the phenotypic level is poorly understood. From comparing the transcriptomes of multiple organs from vertebrate species spanning ~350 million years of evolution, we observe significant differences in alternative splicing complexity between the main vertebrate lineages, with the highest complexity in the primate lineage. Moreover, within as little as six million years, the splicing profiles of physiologically-equivalent organs have diverged to the extent that they are more strongly related to the identity of a species than they are to organ type. Most vertebrate species-specific splicing patterns are governed by the highly variable use of a largely conserved cis-regulatory code. However, a smaller number of pronounced species-dependent splicing changes are predicted to remodel interactions involving factors acting at multiple steps in gene regulation. These events are expected to further contribute to the dramatic diversification of alternative splicing as well as to other gene regulatory changes that contribute to phenotypic differences among vertebrate species.

ORGANISM(S): Mus musculus Anolis carolinensis Gallus gallus Tetraodon nigroviridis Xenopus tropicalis

PROVIDER: GSE41338 | GEO | 2012/12/22

SECONDARY ACCESSION(S): PRJNA176589

REPOSITORIES: GEO

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Project description:The evolutionary landscape of alternative splicing in vertebrate species

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