Role for DNA methylation in Gata4-binding in embryonic stem cells-derived mesoderm
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ABSTRACT: During embryogenesis, many key transcription factors are used repeatedly, achieving different outcomes depending on cell type and developmental stage. The epigenetic modification of the genome functions as a memory of a cell’s developmental history, and it has been proposed that such modification shapes the cellular response to transcription factors. To investigate the role of DNA methylation in the response to transcription factor Gata4, we have tried to identify GATA4-binding associated genes of WT-type and Dnmt3a-/-Dnmt3b-/-(DKO) in Flk1-based mesoderm progenitor by Gata4 ChIP-analysis.
ORGANISM(S): Mus musculus
PROVIDER: GSE41361 | GEO | 2013/06/24
SECONDARY ACCESSION(S): PRJNA176686
REPOSITORIES: GEO
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