Transcriptomics

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MRNA Profiling of Polysome fractions from #483 T-ALL treated with 4EGI-1 or DMSO


ABSTRACT: High activation of the PI3K-AKT-mTOR pathway is characteristic for T-cell acute lymphoblastic leukemia (T-ALL). Here we investigated how 4EGI-1, a small inhibitor of cap-dependent translation, induces apoptosis in T-ALL clones displaying hyperactive PI3K-AKT-mTOR signaling. 4EGI-1 treatment reduced the ribosomal occupancy of transcripts that define the molecular difference between T-ALL blasts and normal thymocytes. These transcripts encoded proteins for the translational machinery, for mitochondrial metabolism as well as oncoproteins such as Cyclin D1, Bcl-2 and c-myc. Therefore, targeting translation initiation proves valuable in situations where mTOR is activated by multiple events.

ORGANISM(S): Mus musculus

PROVIDER: GSE41382 | GEO | 2014/01/01

SECONDARY ACCESSION(S): PRJNA176879

REPOSITORIES: GEO

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