Transcriptomics

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Neutrophils play a key role in schistosome-induced hepatic granuloma formation


ABSTRACT: The severity of schistosome egg-induced hepatic granulomatous pathology depends markedly on the nature of the mammalian host immune response. The local cellular and molecular mechanisms that co-ordinate hepatic granuloma formation during schistosome infection are still poorly understood. We used a combination of laser microdissection microscopy and microarray analysis to further our understanding of fibrogenesis and granuloma formation in C57BL/6 mice infected with Schistosoma japonicum. We compared hepatic gene expression profiles in histologically distinct zones both within, and directly proximal to, granulomas during the course of their development.

ORGANISM(S): Mus musculus

PROVIDER: GSE41941 | GEO | 2012/11/01

SECONDARY ACCESSION(S): PRJNA178550

REPOSITORIES: GEO

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