Zebrafish microRNA miR-430 promotes deadenylation and clearance of maternal mRNAs
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ABSTRACT: MicroRNAs comprise 1-3% of all vertebrate genes, but their in vivo functions and mechanisms of action remain largely unknown. Zebrafish miR-430 is expressed at the onset of zygotic transcription and regulates morphogenesis during early development. Using a microarray approach and in vivo target validation, we find that miR-430 directly regulates several hundred target mRNAs. Targets are highly enriched for maternal mRNAs that accumulate in the absence of miR-430. We also show that miR-430 accelerates the deadenylation of target mRNAs. These results suggest that miR-430 facilitates the deadenylation and clearance of maternal mRNAs during early embryogenesis. Keywords: Dicer, MZdicer, miR-430, miRNA target, maternal, zygotic
ORGANISM(S): Danio rerio
PROVIDER: GSE4201 | GEO | 2006/02/17
SECONDARY ACCESSION(S): PRJNA95055
REPOSITORIES: GEO
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