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Sox4 knockdown in ACC3 cells

ABSTRACT: Sox4 is upregulated in adenoid cystic carcinoma (ACC). The ACC3 cell line is the most widely available cell culture model system of this tumor type. RNAi mediated knockdown of Sox4 in ACC3 cells induces apoptosis. Since Sox4 is a transcription factor, it is hypothesized that this apoptotic phenotype is due to changes in transcription from genes under Sox4 control.This experiment was designed to find candidate genes whose expression levels change after Sox4 knockdown that could contribute to the pro-apoptotic phenotype. Keywords: gene knockdown

ORGANISM(S): Homo sapiens

PROVIDER: GSE4225 | GEO | 2006/07/28

SECONDARY ACCESSION(S): PRJNA94871

REPOSITORIES: GEO

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RNAi knock down of Sox4 in a human adenoid cystic carcinoma cell line reveals that knockdown of Sox4 expression induces apoptosis

Project description:Sox4 is upregulated in adenoid cystic carcinoma (ACC). The ACC3 cell line is the most widely available cell culture model system of this tumor type. RNAi mediated knockdown of Sox4 in ACC3 cells induces apoptosis.

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Expression data from ACC xenografts and normal salivary glands

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