Transcriptomics

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Gene array experiment to identify genes that are upregulated by saturating creatine levels in vitro and potentially inhibiting creatine transporter (CrT) activity


ABSTRACT: We sought to investigate the mechanisms of CrT modulation by saturating extracellular Cr. For this purpose, we used an in vitro system of 3T3 fibroblasts stably overexpressing CrT and followed a global gene array approach to test the hypothesis that saturating intracellular [Cr] increases the expression of candidate molecules that inhibit CrT activity. In this way, we would elucidate mechanisms of redox regulation in cases of fluctuating energy demands.

ORGANISM(S): Mus musculus

PROVIDER: GSE42356 | GEO | 2012/12/07

SECONDARY ACCESSION(S): PRJNA181143

REPOSITORIES: GEO

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