Transcriptomics

Dataset Information

0

Expression data from Tet2-hypomorph (knockdown) and/or Ezh2-null Lineage-Sca-1+c-Kit+ (LSK) cells and granulocyte-macrophage progenitors (GMPs)


ABSTRACT: PcG proteins form the polycomb repressive complexes (PRC) 1 and 2, functioning as transcriptional repressors through histone modifications. They have been implicated in the maintenance of self-renewing somatic and cancer stem cells. PcG genes have been characterized as tumor suppressor genes as exemplified by somatic inactivating mutations of EZH2, a gene encoding histone methyltransferase in PRC2, in myeloid malignancy. Mice deficient for Tet2 have been reported to recapitulate some aspects of myeloid malignancies. We evaluated the Ezh2-deficient mice and also tested the impact of concurrent depletion of Ezh2 and Tet2 on hematopoiesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE42666 | GEO | 2013/08/01

SECONDARY ACCESSION(S): PRJNA182595

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-08-01 | E-GEOD-42666 | biostudies-arrayexpress
2019-12-12 | E-MTAB-8501 | biostudies-arrayexpress
2022-03-28 | GSE161390 | GEO
2018-03-15 | GSE99333 | GEO
2022-03-28 | GSE161391 | GEO
2011-07-01 | E-GEOD-27816 | biostudies-arrayexpress
2015-03-14 | GSE66897 | GEO
2021-04-01 | GSE129886 | GEO
2010-06-30 | E-GEOD-21948 | biostudies-arrayexpress
2010-12-11 | E-GEOD-25706 | biostudies-arrayexpress