Genomics

Dataset Information

0

SAM domain polymerization links subnuclear clustering of PRC1 to silencing (Ring1B ChIP-Seq)


ABSTRACT: Polycomb group (PcG) proteins mediate heritable but reversible silencing of developmental regulator genes by modifying their chromatin configuration. Accumulating evidence documents a role for PcG proteins in regulating higher order chromatin structures likely by their clustering, however, underlying mechanisms and its impact on transcriptional regulation remain obscure. In this study, we found that subnuclear clustering of PRC1 at canonical PcG target genes depended on head-to-tail polymerization property of SAM domain of Phc2 and likely Phc1. We show that Phc2-SAM polymerization limits the dynamic nature of PRC1, thereby promotes stable association of PRC1 with PcG target genes and contributes to their robust silencing. Our findings suggest a novel model by which SAM polymerization of Phc2 modulates the structural organization of PcG complexes to enable robust yet reversible PcG-mediated repression during development.

ORGANISM(S): Mus musculus

PROVIDER: GSE42801 | GEO | 2013/08/07

SECONDARY ACCESSION(S): PRJNA183216

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-06-01 | GSE37530 | GEO
2013-06-01 | E-GEOD-37530 | biostudies-arrayexpress
2013-06-01 | GSE37346 | GEO
2013-06-01 | GSE37526 | GEO
2013-06-01 | E-GEOD-37346 | biostudies-arrayexpress
2013-08-07 | E-GEOD-42801 | biostudies-arrayexpress
2013-06-01 | GSE38154 | GEO
2013-06-01 | E-GEOD-37526 | biostudies-arrayexpress
2013-06-01 | E-GEOD-38154 | biostudies-arrayexpress
2016-01-14 | GSE72830 | GEO