Differentially regulated genes in TOR knockdown Arabidopsis lines
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ABSTRACT: Rapamycin-sensitive transgenic Arabidopsis lines (BP12) expressing yeast FK506 Binding Protein12 (FKBP12) were developed. Inhibition of TOR in BP12 plants by rapamycin resulted in slower overall root, leaf and shoot growth and development leading to poor nutrient uptake and light energy utilization. Genetic and physiological studies together with RNA-Seq and metabolite analysis of TOR-suppressed lines revealed that TOR regulates development and lifespan in Arabidopsis by restructuring cell growth, carbon and nitrogen metabolism, gene expression, ribosomal RNA and protein synthesis.
ORGANISM(S): Arabidopsis thaliana
PROVIDER: GSE42968 | GEO | 2012/12/18
SECONDARY ACCESSION(S): PRJNA183972
REPOSITORIES: GEO
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