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Sex Differences in Response to Plasmodium chabaudi Infection: Involvement of Gonadal Steroids

ABSTRACT: The goal of this study was to examine whether immune responses to Plasmodium chabaudi infection differ between the sexes and are altered by the presence of gonadal steroids. Gonadally-intact males were more likely than intact females to die following P. chabaudi infection, exhibit slower recovery from infection-associated weight loss, hypothermia, and anemia, have reduced IFNγ-associated gene expression and IFNγ production during peak parasitemia, and produce less antibody during the recovery phase of infection. Gonadectomy of male and female mice altered these sex-associated differences, suggesting that sex steroid hormone, in particular androgens and estrogens, may modulate immune responses to infection. Keywords: Time Course

ORGANISM(S): Mus musculus

PROVIDER: GSE4324 | GEO | 2006/06/01

SECONDARY ACCESSION(S): PRJNA94747

REPOSITORIES: GEO

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