In-vitro differentiated midbrain dopaminergic neurons from isogenic human induced pluripotent stem cells

ABSTRACT: We have generated isogenic induced pluripotent stem cell lines by reprogramming human fibroblasts from patients carrying the LRRK2 G2019S mutation with subsequent zinc finger nuclease - mediated targeted correction of the diseased allele. These iPS cell lines were differentiated for 30 days using a direct differentiation protocol towards midbrain dopaminergic neurons (mDANs).

ORGANISM(S): Homo sapiens

PROVIDER: GSE43364 | GEO | 2013/03/07

SECONDARY ACCESSION(S): PRJNA185600

REPOSITORIES: GEO