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MicroRNA profiling in primary and metastatic HCC cell lines using PLC8024 and MHCC97H derived cell lines

ABSTRACT: Goal for this study is to identified miRNA involved in metastasis development using PLC8024 and MHCC97H derived cell lines.

ORGANISM(S): Rattus norvegicus Mus musculus Danio rerio Homo sapiens Caenorhabditis elegans Drosophila melanogaster

PROVIDER: GSE43445 | GEO | 2013/01/12

SECONDARY ACCESSION(S): PRJNA186435

REPOSITORIES: GEO

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MicroRNA profiling in primary and metastatic HCC cell lines using PLC8024 and MHCC97H derived cell lines

Project description:Goal for this study is to identified miRNA involved in metastasis development using PLC8024 and MHCC97H derived cell lines. PLC8024 derived cell lines, PLC-PT (Primary Tumor) and PLC-LM (Lung Metastasis), and MHCC97H derived cell lines, MHCC97H-PT and MHCC97H-LM were compared using the Ncode miRNA microarray platform. The experiment were repeat twice with dye-swap.

2013-01-12 | E-GEOD-43445 | biostudies-arrayexpress

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Effects of UBXN1 knockdown on gene expression in MHCC97H cell lines

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Project description:MHCC97H cell, a human hepatocellular carcinoma (HCC) cell line, was stably overexpressed with empty vector, ACOT12, or ACOT12(RR312,313EE) mutant (ACOT12m). These cells were then used for gene expression profiles analysis.

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Project description:The prognosis of hepatocellular carcinoma (HCC) is poor due to the high incidence of intrahepatic metastasis. The aim of this study is to investigate the mechanism of intrahepatic metastasis in HCC via extracellular vesicles (EVs).

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LncRNA regulated by hnRNPAB in HCC cell lines

Project description:To reveal the HNRNPAB-regulated lncRNAs, we performed microarray analyses to screen differential lncRNAs in HCC cells after stable overexpression or knockdown of HNRNPAB. MHCC97H and HCCLM3 (HCC cell lines with high-metastatic potentials), PLC/PRF/5 and HepG2 (HCC cell lines with low-metastatic potentials) were used in this study. HepG2-control, HepG2-hnRNPAB, PLC/PRF/5-control, PLC/PRF/5-hnRNPAB, MHCC97H-control, MHCC97H-sh-hnRNPAB, HCCLM3-control, HCCLM3-sh-hnRNPAB were perpared with hU6-MCS-CBh-gcGFP-IRES-puromycin-shRNA-HNRNPAB/mock lentiviral and Ubi-MCS-SV40-EGFP-IRES-puromycin-HNRNPAB/mock cDNA lentiviral,respectively, each performed in triplicate.

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Effect of depletion or overexpression of EGR1 on gene expression in HCC cells (deletion in MHCC97H cells, overexpression in PLC/PRF5 cells)

Project description:To investigate the function of EGR1 in HCC growth, we established EGR1 knock out MHCC97H cells by CRISPR/Cas9 system and EGR1-overexpressing PLC/PRF5 cells. We then performed gene expression profiling analysis using data obtained from RNA-seq of EGR1 knock out MHCC97H cells and parental MHCC97H cells, EGR1-overexpressing PLC/PRF5 cells and control PLC/PRF5 cells.

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Effects of UBXN1 knockdown on gene expression in MHCC97H cell lines

Project description:Effects of UBXN1 knockdown on gene expression in MHCC97H cell lines

| PRJNA1037471 | ENA

Investigation of downstream genes regulated by ACOT12 in HCC cells [MHCC97H]

Project description:Investigation of downstream genes regulated by ACOT12 in HCC cells [MHCC97H]

| PRJNA438078 | ENA

Expression data from heat-damaged MHCC97H treated by HGF

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