Transcriptomics

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LncRNAs expression profiles in the livers of C57Bl/6 mice after partial hepatectomy


ABSTRACT: Liver regeneration has important implications because many therapeutic strategies for the surgical treatment of liver diseases, such as removal of liver tumors and liver transplantation, depend on the ability of the liver to regenerate physically and functionally. Recent studies reported that lncRNAs control cell proliferation in hepatocellular carcinoma (HCC). However, the role of lncRNAs in liver regeneration and the overall mechanisms remain largely unknown. To address this issue, we carried out a genome-wide lncRNA microarray analysis during liver regeneration in mice after 2/3 partial hepatectomy (PH) at various time points. The results revealed differential expression of thousands of lncRNAs during liver regeneration.

ORGANISM(S): Mus musculus

PROVIDER: GSE43687 | GEO | 2013/04/24

SECONDARY ACCESSION(S): PRJNA187058

REPOSITORIES: GEO

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