Genomics

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Identification of miRNA differential expression patterns in a new model of acquired letrozole resistance


ABSTRACT: Since differential miRNA expression patterns associated with acquired AI resistance have been poorly investigated, the aim of this study was to delineate the deregulation of miRNA expression associated with aromatase inhibitor (AI) response failure in new cellular models of AI resistance. For this purpose, we generated and characterized novel cellular models of acquired resistance to letrozole (Res-Let cells) and to anastrozole (Res-Ana cells) and performed microarray experiments to identify miRNAs whose expression was either deregulated between control (MCF-7aro) and resistant cells (Res-Let or Res-Ana). With the aim to select relevant miRNAs, two independent cell culture replicates were performed for each experimental condition.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE43766 | GEO | 2013/01/30

SECONDARY ACCESSION(S): PRJNA187554

REPOSITORIES: GEO

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