Genome-wide analysis of interleukin (IL) -6 and IL-11 responsive genes in murine gastric tumors
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ABSTRACT: We performed micrarrays to analyse gene expression in spontaneously arising gastric tumors from gp130Y757F/F mutant mice (Tebbutt et al., 2002) following administration of recombinant human IL-6 or IL-11. The present study was designed to assess differences in gene expression in response to IL-6 and IL-11, two cytokines which both activate the shared gp130 receptor and downstream Stat3 signalling pathway. Since gastric tumorigenesis in gp130Y757F/F mice is strictly dependent on IL-11, but not IL-6 signalling (Ernst et al., 2008) the study aimed to identify IL-6 and IL-11 specific target genes which may account for the IL-11 dependent tumor development.
ORGANISM(S): Mus musculus
PROVIDER: GSE43800 | GEO | 2013/08/10
SECONDARY ACCESSION(S): PRJNA187455
REPOSITORIES: GEO
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