Transcriptomics

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Identification of novel metastases-suppressor genes involved in breast cancer brain metastases (BCBM) formation


ABSTRACT: Initial screening for potential metastases suppressors down regulated by methylation was performed using breast cancer cell line models specific for site-specific metastasation. Gene expression profiling and qRT-PCR validations were conducted on tumor tissues from primary breast cancer (BC) and BCBM. CADM1 and RECK were further characterized for their methylation patterns and finally the protein expression of CADM1 was validated in a large number of BC and BCBM samples and correlated with clinico-pathologic parameters.

ORGANISM(S): Homo sapiens

PROVIDER: GSE44354 | GEO | 2014/03/04

SECONDARY ACCESSION(S): PRJNA190627

REPOSITORIES: GEO

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