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Genome-wide binding of TEAD4 in gastric cancer cell lines MKN28 and SNU216

ABSTRACT: To access target binding sites of TEAD4 in gastric cancer, TEAD4 binding was investigated using MKN28 and SNU216 cell lines by ChIP-seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE44416 | GEO | 2014/01/02

SECONDARY ACCESSION(S): PRJNA189846

REPOSITORIES: GEO

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Genome-wide binding of TEAD4 in gastric cancer cell lines MKN28 and SNU216

Project description:To access target binding sites of TEAD4 in gastric cancer, TEAD4 binding was investigated using MKN28 and SNU216 cell lines by ChIP-seq. MKN28 and SNU216 cell lines were cross-linked with formaldehyde, fractionated by sonication and immunoprecipitated by TEAD4 antibody. Immunoprecipitated DNA was prepared by generating libraries and sequenced by massive parallel sequencing.

2014-01-02 | E-GEOD-44416 | biostudies-arrayexpress

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Project description:To investigate the effect of STAT3 activation on the expression of gastric cancer cells, expression profile was compared in MKN28 cells overexpressed with control vector vs mouse constitutively activated STAT3 mutant (STAT3c). MKN28 gastric cancer cells were transfected with pcDNA3.1 (vector control) or plasmid overexpressing STAT3c (treatment). Stable clones were selected for RNA extraction and expression microarray analysis (Agilent). Experiments were repeated twice.

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Effect of STAT3c on the gene expression of MKN28 gastric cancer cells

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Transcritomic analysis of PHF8 mediated genes in MKN28, human gastric cancer cells

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