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MiRNA expression changes in murine liver tumorigenesis

ABSTRACT: Hepatocellular carcinoma (HCC) is associated with poor survival for patients and few effective treatment options, raising the need for novel therapeutic strategies. MicroRNAs (miRNAs) play important roles in tumor development and show deregulated patterns of expression in HCC. Because of the liver’s unique affinity for small nucleic acids, miRNA based therapy has been proposed in the treatment of liver disease. There is thus an urgent need to identify and characterize aberrantly expressed miRNAs in HCC. In our study, we profiled miRNA expression changes in de novo liver tumors driven by MYC and/or RAS, two canonical oncogenes activated in a majority of human HCC.

ORGANISM(S): Oryza sativa Caenorhabditis elegans Mus musculus Rattus norvegicus synthetic construct Homo sapiens Populus trichocarpa

PROVIDER: GSE44570 | GEO | 2013/09/01

SECONDARY ACCESSION(S): PRJNA190086

REPOSITORIES: GEO

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miRNA expression changes in murine liver tumorigenesis

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