Transcriptomics

Dataset Information

0

Vitamin-D Responsive SGPP2 Variants Associated with Lung Cell Expression and Lung Function


ABSTRACT: Background: Vitamin D is associated with lung health in epidemiologi studies, but mechanisms mediating observed associations are poorly understood. This study explores mechanisms for an effect of vitamin D in lung through an in vivo gene expression study, an expression quantitative trait loci (eQTL) analysis in lung tissue, and a population-based cohort study of sequence variants. Methods: Microarray analysis investigated the association of gene expression in small airway epithelial cell with serum 25[OH]D in adult nonsmokers. Sequence variants in candidate genes identified by the microarray were investigated in a lung tissue eQTL database, and also in relation to cross-sectional pulmonary function in Health, Aging, and Body Composition [Health ABC] study, stratified by race, with replication in the Framingham Heart Study [FHS]. Results: 13 candidate genes had significant differences in expression by serum 25[OH]D (nominal p<0.05), and a genome-wide significant eQTL association was detected for SGPP2. In Health ABC, SGPP2 SNPs were associated with FEV1 in both European and African-Americans, and the gene-level association was replicated in European-American FHS participants. SNPs in 5 additional candidate genes (DAPK1, FSTL1, KAL1, KCNS3 and RSAD2) were associated with FEV1 in Health ABC participants. Conclusions: SGPP2, a sphingosine-1-phosphate, is a novel vitamin D-responsive gene associated with lunh function. The identified associations will need to be followed up in further studies.

ORGANISM(S): Homo sapiens

PROVIDER: GSE44865 | GEO | 2024/06/05

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-09-09 | GSE212728 | GEO
2021-02-25 | GSE167429 | GEO
2021-02-25 | GSE167411 | GEO
2021-02-25 | GSE167412 | GEO
2016-04-07 | E-GEOD-70468 | biostudies-arrayexpress
2008-05-31 | GSE8581 | GEO
2024-05-15 | GSE247667 | GEO
2016-04-07 | GSE70468 | GEO
2024-05-15 | GSE250048 | GEO
2016-08-09 | PXD003292 | Pride