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Expression data by BRD7552 treatment in PANC-1 cells

ABSTRACT: Three master regulatory transcription factors Pdx1, MafA and Ngn3 have the ability to transdifferentiate pancreatic acinar cells to insulin-producing beta cells in mice. BRD7552 was identified as a small-molecule inducer that can upregulate the expression of Pdx1 in PANC-1 cells by high-throughput qPCR screening. We used microarrays to illustrate the mechnism of BRD7552 for PDX1 and insulin induction.

ORGANISM(S): Homo sapiens

PROVIDER: GSE44946 | GEO | 2013/03/10

SECONDARY ACCESSION(S): PRJNA192593

REPOSITORIES: GEO

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Expression data by BRD7552 treatment in PANC-1 cells

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