Genomics

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ChIP-DSL H20K promoter array from human gastric cancer cells MKN28 with Sox2 overexpression


ABSTRACT: The transcription factor Sox2 inhibits human gastric cancer growth and activates Sox2-related tumor surpressive genes in human gastric cancer cells. Conditional Sox2-overexpression in cells with a low Sox2 level demonstrated that the Sox2-regulated tumor surpressive genes demand on an enhanced Sox2 activity for better expression to work in human gastric cancer. Chromatin immunoprecipitation (ChIP) of Sox2 together with chromatin profiling by ChIP-on-chip analysis demonstrated that Sox2 directly activates the chromatin at promoters or putative enhancers of Sox2 target genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE45427 | GEO | 2013/05/22

SECONDARY ACCESSION(S): PRJNA193701

REPOSITORIES: GEO

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