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Does Phosphatidylserine (PS) affect gene expression in FD mice?

ABSTRACT: Genes associated with transcription regulation and development processes were up-regulated in the cerebrum of PS-treated mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE45580 | GEO | 2013/04/02

SECONDARY ACCESSION(S): PRJNA195559

REPOSITORIES: GEO

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Does Phosphatidylserine (PS) affect gene expression in FD mice?

Project description:Genes associated with transcription regulation and development processes were up-regulated in the cerebrum of PS-treated mice. at 4 months of age 6 FD mice were gavaged with either 200mg/kg PS (3 mice) or medium-chain triglycerides (MCT, 3 mice) every other day for a period of 3 months

2013-04-02 | E-GEOD-45580 | biostudies-arrayexpress

Expression and neurobehavioral analyses in prosaposin deficient mice: Molecular alterations precede neuronal deficits

2008-08-08 | GSE8307 | GEO

Transcription profiling of prosaposin deficient mice show molecular alterations precede neuronal deficits

Project description:Prosaposin encodes, in tandem, four small acidic activator proteins (saposins) with specificities for glycosphingolipids hydrolases in lysosomes. To explore the molecular mechanism(s) of disease progression, temporal transcriptome microarray analyses of cerebrum and cerebellum tissues were conducted using mRNA from three prosaposin deficiency mouse models: PS-NA (hypomorphic prosaposin deficiency), PS-/- (prosaposin null) and 4L/PS-NA (a V394L/V394L glucocerebrosidase mutation and PS-NA) mice. Our results indicate that regionally specific gene expression abnormalities preceded the histological and behavioral changes and CEBPD is a candidate regulator of brain disease in prosaposin deficiency. The alterations of gene expression are detected at birth and are more profound in cerebellum than cerebrum. Experiment Overall Design: In order to increase the temporal resolution of expression profile in brain, the disease progression in those models were inverstigated in two regions of brains (cerebellum and cerebrum) at three or four time points according to the genotypes. PS-/-: new born (0d), 10 days (10d), 20 days (20d), 25 days (25d); PS-NA: new born, 4 weeks (4w), 12 weeks (12w), 18 weeks (18w); 4L/PS-NA: 4 weeks (4w), 12 weeks (12w), 18 weeks (18w). The data from those models were analyzed relative to the corresponding wild type at same time point (0d, 10d, 20d, 4w, 12w, 18w).

2008-10-01 | E-GEOD-8307 | biostudies-arrayexpress

RNAseq analysis of PS+ vs. PS- effector CD8 T cells sorted from spleen of LCMV-Armstrong infected mice

Project description:We report the transcriptional profile of phosphatidylserine (PS) positive and PS negative CD44+CD62L- effector CD8+ T cells from LCMV-Armstrong infected mice sorted from spleens on day5 amd day10 after infection. PS was stained in vivo by injection of MFG-E8-eGFP. PS+ cells acquire PS through binding of extracellular vesicles (EVs). Binding of EVs by effector CD8+ T cells is strongly enhanced during LCMV infection and peaks between day5 and day10 post infection. Effector T cell gene signature is increased in EV+ CD8+ T cells compared to their EV- counterparts.

2023-03-29 | GSE201507 | GEO

Azospira oryzae PS strain:PS

Project description:Azospira oryzae PS strain:PS Genome sequencing

| PRJNA250450 | ENA

RNAseq analysis of PS+ vs PS- non-naive CD8 T cells sorted from peripheral blood of COVID-19 patients

Project description:We report the transcriptional profile of phosphatidylserine (PS) positive and PS negative non-naive peripheral blood CD8 T cells from patients infected with SARS-CoV-2. PS+ CD8 T cells showed increased expression of cell cyclce and cell division associated genes and reduced expression of genes regulating translational initiation, when compared to PS- CD 8 T cells. Furthermore, PS+ CD8 T cells show increased expression of effector T cell genes.

2021-05-21 | GSE174786 | GEO

Escherichia coli PS strain:PS

Project description:Escherichia coli PS genome sequencing

| PRJNA59639 | ENA

Methanococcus voltae PS strain:PS

Project description:Methanococcus voltae PS genome sequencing

| PRJNA834340 | ENA

Azospira oryzae PS strain:PS

Project description:Dechlorosoma suillum PS genome sequencing project

| PRJNA37693 | ENA

RNA sequencing (RNA-seq) analysis of leaf and root of Col grown on 1/2 MS with or without PS-SO3H or PS-NH2 nanoplastics treatment

Project description:The goals of this study are to find the differential expression genes after PS-SO3H or PS-NH2 nanoplastics treatment, to explain why the PS-SO3H or PS-NH2 nanoplastics have inhibited the root growth.

2018-12-07 | GSE123369 | GEO

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