Transcriptomics

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FoxO1 Controls Effector to Memory Transition and Maintenance of Functional CD8 T-Cell Memory


ABSTRACT: During a T cell response, naïve CD8 T cells differentiate into effector cells. Subsequently, a subset of effector cells termed memory precursor effector cells (MPECs) further differentiates into functionally mature memory CD8 T cells. The transcriptional network underlying this carefully scripted process is not well understood. Here, we report that the transcription factor FoxO1 plays an integral role in facilitating effector to memory transition and functional maturation of memory CD4 and CD8 T cells. We find that FoxO1 is not required for differentiation of effector cells, but in the absence of FoxO1, memory CD8 T cells displayed features of scenescence and progressive attrition in polyfunctionality, which in turn led to impared recall responses and poor protective immunity. These data suggest that FoxO1 is essential for active maintenance of functional CD8 T cell memory and protective immunity. Under competing conditions in bone marrow

ORGANISM(S): Mus musculus

PROVIDER: GSE45673 | GEO | 2013/06/25

SECONDARY ACCESSION(S): PRJNA195588

REPOSITORIES: GEO

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