Project description:To further study the transcriptome of human mammary epithelial cells (HMEC 184) after exposure to polymeric Eudragit RS nanoparticles (ENP), we investigate whole genome microarray expression to identify genes regulated by exposure or not to ENP. Changes in gene expression in HMEC 184 cells (50M-BM- % confluence) incubated with 25M-BM- M-BM-5g/mL ENPs (70M-BM- nm) for 24M-BM- h, and without incubation (control) were measured. Three biological replicates were performed as controls (US_01; US_02; US_04) and ENP exposed ones (US_6; US_07; US_08).

2013-08-01 | E-GEOD-45598 | biostudies-arrayexpress

Transcriptome study of human mammary epithelial cells following exposure to polymeric Eudragit RS nanoparticles part 2

Project description:To further study the transcriptome of human mammary epithelial cells (HMEC 184) after exposure to polymeric Eudragit RS nanoparticles (ENP), we investigate whole genome microarray expression to identify genes regulated by exposure or not to ENP. Changes in gene expression in HMEC 184 cells (90M-BM- % confluence) incubated with 25M-BM- M-BM-5g/mL ENPs (70M-BM- nm) for 24M-BM- h, and without incubation (control) were measured. Three biological replicates were performed as controls (US_09; US_10; US_11) and ENP exposed ones (US_12; US_13; US_14).

2013-08-01 | E-GEOD-45868 | biostudies-arrayexpress

Transcriptome study of human mammary epithelial cells following exposure to polymeric Eudragit RS nanoparticles

Project description:Transcriptome study of human mammary epithelial cells following exposure to polymeric Eudragit RS nanoparticles

| PRJNA196516 | ENA

Transcriptome study of Caco-2 human intestinal cells following exposure to empty or S-nitrosoglutathione-loaded polymeric nanoparticles

Project description:To further study the transcriptome of Caco-2 human colon epithelial-like cells after exposure to S-nitrosoglutathione (GSNO, 1.4 μM), or Eudragit RL PO polymeric nanoparticles (NP-ERL, 50 μg/mL) or GSNO loaded nanoparticles (NP-GSNO, 50 μg/mL corresponding to (1.4 μM GSNO) we investigate whole genome microarray to identify genes regulates by exposure or not to GSNO (1.4 μM) or Eudragit RL PO polymeric nanoparticles (NP-ERL, 50 μg/mL) or GSNO loaded nanoparticles (NP-GSNO, 50 μg/mL corresponding to (1.4 μM GSNO).

2015-12-31 | GSE69551 | GEO

Transcriptome study of Caco-2 human intestinal cells following exposure to empty or S-nitrosoglutathione-loaded polymeric nanoparticles

Project description:To further study the transcriptome of Caco-2 human colon epithelial-like cells after exposure to S-nitrosoglutathione (GSNO, 1.4 Î¼M), or Eudragit RL PO polymeric nanoparticles (NP-ERL, 50 Î¼g/mL) or GSNO loaded nanoparticles (NP-GSNO, 50 Î¼g/mL corresponding to (1.4 Î¼M GSNO) we investigate whole genome microarray to identify genes regulates by exposure or not to GSNO (1.4 Î¼M) or Eudragit RL PO polymeric nanoparticles (NP-ERL, 50 Î¼g/mL) or GSNO loaded nanoparticles (NP-GSNO, 50 Î¼g/mL corresponding to (1.4 Î¼M GSNO). Changes in gene expression in Caco-2 cells incubated without (control) or with GSNO or nanoparticles for 4 h, were measured. Four biological replicates were performed as controls: S46_1_4 ; S46_1_3 ; S35_1_4 ; S35_1_3. Four biological replicates were performed for each conditions : wtih GSNO (1.4 ÂµM) exposed cells (S46_2_2 ; S46_2_1 ; S35_2_2 ; S35_2_1), with NP-ERL (50 Î¼g/mL) exposed cells (S46_1_2 ; S46_1_1 ; S35_1_2 ; S35_1_1) with NP-GSNO (50 Î¼g/mL corresponding to 1.4 ÂµM GSNO) exposed cells (S46_2_4 ; S46_2_3 ; S35_2_4 ; S35_2_3)

2015-12-31 | E-GEOD-69551 | biostudies-arrayexpress

Unique growth pattern of human mammary epithelial cells induced by polymeric nanoparticles.

Project description: Not available

| S-EPMC3831889 | biostudies-literature

Transcriptomic study of NR8383 cells following exposure to zinc oxide nanoparticles NM110

Project description:To identify differentially expressed genes and key biological pathways that define toxicity following nanoparticle exposure, we performed microarray analyses on NR8383 macrophages exposed for 4 h to 2 µg/mL of NP ZnO (20 % cell viability). This project (SmartNanoTox) has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 686098.

2020-04-12 | GSE97852 | GEO

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