Investigation of Alterations in Gene Expression in the Retina Induced by Intravitreal Injection of SH-42 and SH-80
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ABSTRACT: In this study, we demonstrate that SH-42 and SH-80, novel heat shock protein 90 inhibitors, suppress retinal neovascularization via inhibition of hypoxia-mediated angiogenesis. To figure out any genotoxic effect of these compounds related with heat shock protein 90 inhibition, we performed microarray analyses with retinal tissues treated with SH-42 and SH-80 for 7 days.
ORGANISM(S): Mus musculus
PROVIDER: GSE46057 | GEO | 2013/04/16
SECONDARY ACCESSION(S): PRJNA197139
REPOSITORIES: GEO
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