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Expression data of multiple sclerosis patients receiving Interferon-beta therapy [miRNA-2_0]

ABSTRACT: The purpose of this study was to investigate the expression dynamics of mRNAs and microRNAs in response to subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) or relapsing-remitting type of the disease (RRMS). By using Affymetrix microarrays, we obtained microRNA expression profiles of peripheral blood mononuclear cells from 3 patients within the first month of IFN-beta treatment.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE46282 | GEO | 2013/04/24

SECONDARY ACCESSION(S): PRJNA198640

REPOSITORIES: GEO

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Expression data of multiple sclerosis patients receiving Interferon-beta therapy [miRNA-2_0]

Project description:The purpose of this study was to investigate the expression dynamics of mRNAs and microRNAs in response to subcutaneous IFN-beta-1b treatment (Betaferon, 250 Âµg every other day) in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) or relapsing-remitting type of the disease (RRMS). By using Affymetrix microarrays, we obtained microRNA expression profiles of peripheral blood mononuclear cells from 3 MS patients within the first month of IFN-beta treatment. EDTA blood samples were taken from all patients immediately before first IFN-beta injection as well as after 1 month. Total RNA of Ficoll-isolated peripheral blood mononuclear cells from each sample was extracted, labeled and hybridized to Affymetrix GeneChip miRNA 2.0 arrays to quantify the expression of small non-coding RNA transcripts. This GEO entry provides the GeneChip miRNA 2.0 microarray data.

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