Genomics

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Human esophageal dysplasia (16 cases) vs. esophageal squamous cell carcinoma (59 cases)


ABSTRACT: Our aim is to identify frequent genomic aberrations both in ESCC and esophageal dysplasia, and to discover important copy number-driving genes and microRNAs in ESCC. We carried out array-based comparative genomic hybridization (array CGH) on 59 ESCC resection samples and 16 dysplasia biopsy samples. Expression of genes at 11q13.3 was analyzed by real-time PCR and immunohistochemistry (IHC). Integrated analysis was performed to identify genes or microRNAs with copy number-expression correlations.

ORGANISM(S): Homo sapiens

PROVIDER: GSE46452 | GEO | 2013/04/29

SECONDARY ACCESSION(S): PRJNA200559

REPOSITORIES: GEO

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